The "Lambert-Eaton Myasthenic Syndrome (LEMS) – Market Insights, Epidemiology, and Market Forecast-2030" drug pipelines has been added to ResearchAndMarkets.com's offering. Aug 24, 2020 (The Expresswire) —
2020 “Azimuth Thrusters Market”:-An azimuth thruster is a configuration of marine propellers placed in pods that can be… Data from Google Trends indicates that there’s a massive spike in the interest in cryptocurrency. … Signs of Bullish Crypto Market Expectations | Bitcoin News Summary Aug 24, 2020 Read More » As just posted, the lockdown restrictions in the country’s largest city of Auckland have been extended another week
The NZD has not done a lot today, just a touch on the weak side as of now:
By Eamonn Sheridan The price of gold appears to be stuck in a continuation pattern after marking the longest stretch of gains (nine consecutive weeks) since 2006. DIXON — Dozens of people gathered in front of the Dixon post office Saturday morning to show support for an institution they fear is under attack from its own Postmaster General.
DUBLIN, Aug. 24, 2020 /PRNewswire/ — The “Lambert-Eaton Myasthenic Syndrome (LEMS) – Market Insights, Epidemiology, and Market Forecast-2030” drug pipelines has been added to ResearchAndMarkets.com’s offering.
The report delivers an in-depth understanding of the LEMS, historical and forecasted epidemiology as well as the LEMS market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.
The report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM LEMS market size from 2017 to 2030. The report also covers current LEMS treatment practice/algorithm, market drivers, market barriers, SWOT analysis, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent Cases of LEMS, Total Diagnosed Prevalent Cases of LEMS, Gender-specific Diagnosed Prevalent Cases of LEMS, Type-specific Diagnosed Prevalent Cases of LEMS, and Diagnosed Prevalent Cases of LEMS by Malignancy scenario of LEMS in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2017 to 2030.
Total prevalent cases of LEMS in the 7MM was found to be 5,977 in 2017.
Based on the etiology, LEMS is divided into two types; paraneoplastic and idiopathic. There were a total 1,978 diagnosed prevalent cases of LEMS in the United States in 2017, out of which 1,154 accounted for paraneoplastic and 824 cases accounted for idiopathic.
As per the assessments, in the 7MM, the majority of cases of LEMS are paraneoplastic form as compared to idiopathic form.
Among the two forms of LEMS, the paraneoplastic form constitutes more than half of the cases and is mostly associated with intrathoracic neoplasms. Most of the cases were seen with small cell lung cancer (SCLC); other subtypes of lung cancer are extremely rare.
Among the EU-5 countries, Germany witnessed the highest prevalent population accounting for 6.93% of the total prevalent cases in 7MM, followed by France and the United Kingdom. On the other hand, Spain witnessed the lowest number of prevalent cases in 2017.
Japan was assessed with 21.32% of the total prevalent population, with 1,274 cases observed in 2017.
The drug chapter segment of the LEMS report encloses the detailed analysis of LEMS marketed drugs, mid-phase, and late-stage pipeline drugs. It also helps to understand the LEMS clinical trial details, expressive pharmacological action, agreements and collaborations, approval, and patent details of each included drug and the latest news and press releases.
Firdapse: Catalyst Pharmaceutical
Firdapse (amifampridine) is a potassium channel blocker used to treat LEMS in adults. The active ingredient of Firdapse is amifampridine phosphate, which is a voltage-gated potassium channel blocker. Amifampridine phosphate is described chemically as 3, 4-diaminopyridine phosphate. Each Firdapse tablet contains 10 mg amifampridine (equivalent to 18.98 mg amifampridine phosphate). The drug was developed by BioMarin Pharmaceutical and is marketed by Catalyst Pharmaceutical, which secured the marketing rights to Firdapse in North America.
In June 2019, Catalyst Pharmaceutical filed a lawsuit against the US FDA over the regulatory agency’s decision to approve a rival treatment for its newly-approved LEMS. Documents released in court, including partially redacted emails from the FDA, appear to show that issues regarding the list price for Firdapse (amifampridine). The lawsuit alleges that the approval of Ruzurgi, a rival drug from privately held Jacobus Pharmaceutical Co, in May 2019, violated provisions of FDA regulations and Catalyst’s rights to exclusivity for its drug, Firdapse.
Catalyst recently announced plans to expand sales to Japan. They recently had talks with the Japanese Ministry of Health, Labor and Social Affairs (MHLW) to get Firdapse approved in Japan.
Ruzurgi: Jacobus Pharmaceutical Company Inc.
Ruzurgi (amifampridine) is a potassium channel blocker indicated for the treatment of LEMS in patients 6 years to less than 17 years of age. It is supplied as a tablet for oral administration. Ruzurgi is designed to prolong signals that are released from nerves to allow greater stimulation of the muscle. Ruzurgi works in a similar mechanism to Firdapse (amifampridine phosphate), which was approved in 2018 for the treatment of adults with LEMS. The drug was initially developed as a phosphate salt of amifampridine by Assistance Publique Hpitaux de Paris. It was later developed and commercialized by various companies, including BioMarin Pharmaceutical, Catalyst Pharmaceuticals, and Jacobus Pharmaceutical.
The therapeutic market of LEMS in the seven major markets was assessed to be USD 59.43 million in 2017 (With Base Case Scenario* and Downside Scenario**) and is expected to grow during the study period (2017-2030).
Currently, there is no cure for LEMS and treatment is mainly symptomatic. This includes 3, 4-diaminopyridine phosphate (DAP), which is usually well-tolerated and effective. In some patients, the combination of pyridostigmine with 3, 4-DAP has been suggested to have an additional positive effect. If symptomatic treatment is insufficient, immunosuppressive therapy with prednisone, alone or in combination with azathioprine, can achieve long-term control of the disorder. Plasmapheresis and high dose administration of intravenous immunoglobulins (IVIGs) have a short effect. An effective treatment against any tumor present is mandatory, both to control the tumor and to improve the clinical symptoms of LEMS.
So far, there are only two FDA approved the medication for LEMS, i.e., Firdapse and Ruzurgi. The FDA’s approval of Firdapse is a potentially transformative milestone in the lives of patients in the US suffering from LEMS, as it now gives adult LEMS patients access to a new first-in-class-therapy. Firdapse is approved in the US and the European Union for use by patients with LEMS.
After the approval of Firdapse, Ruzurgi is the second drug to be approved in the US for the treatment of LEMS and first approved the medication for the treatment of LEMS in patients 6 years to less than 17 years of age. Despite being a potential therapy in the treatment, a lawsuit has been filed by Catalyst Pharma against the US FDA and several related parties challenging the recent approval of an NDA and related drug labeling for Ruzurgi for the treatment of LEMS in pediatric patients. The lawsuit alleges that the approval of Ruzurgi, Catalyst’s rival medicine from privately held Jacobus Pharmaceutical, in May violated provisions of US FDA’s regulations and Catalyst’s rights to exclusivity for its drug, Firdapse. Both drugs are approved to treat LEMS, but Firdapse was approved for adults, while Jacobus’ drug was for children.
Presently there are no approved therapies of LEMS in Japan, Catalyst Pharma announced the plan to expand sales of Firdapse in Japan. They recently had talks with the Japanese Ministry of Health, Labor and Social Affairs (MHLW) to get Firdapse approved in Japan. About two years ago, the Japanese government approved Firdapse as a primary drug for the MHLW and actively asked companies to develop and submit an NDA for the drug. Once Catalyst and MHLW have reached agreement on what will be required to file this NDA in Japan, an update of the approval process for filing an NDA in Japan will be released.
*Base Case Scenario: With the Base Case Scenario, the research analysts estimate that Ruzurgi will not be launch in the market because Catalyst has filed a suit against Jacobus’ drug (Ruzurgi). Therefore, it is estimated that Firdapse will cover a decent market in the upcoming years without any competition
**Downside Scenario: With Downside Scenario, the publisher is expecting the launch of Ruzurgi in the United States in the second half of 2020, which will compete and likely to take the market share of Firdapse.
In 2017, the market size of LEMS in the 7MM was USD 59.43 million.
Among the 7MM, the United States accounted for the majority of the market size with USD 32.85 million in 2017.
The current market size of LEMS is entirely dependent on symptomatic treatment regimens, includes Firdapse, 3, 4-diaminopyridine (base), pyridostigmine, immunoglobulin, and others). Others include guanidine, acetylcholinesterase (AChE) inhibitors, prednisone, azathioprine, cyclosporine, and plasmapheresis.
Firdapse (Catalyst Pharmaceuticals) is the only approved therapy for the treatment of LEMS in adults in the United States and EU5.
Another Molecule Ruzurgi (Jacobus Pharmaceuticals), is approved by the US FDA in May 2019, for the treatment of patients with LEMS age six to less than 17 years. However, In June 2019, Catalyst filed its lawsuit in the US District Court for the Southern District of Florida and is seeking a reversal of FDA’s decision.
The publisher estimates that Japan has the second-highest market size after the United States in 2017, which accounted for USD 9.59 million.
This section focusses on the rate of uptake of the potential drugs recently launched in the LEMS market or expected to get launched in the market during the study period 2017-2030. The analysis covers LEMS market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In the report, we consider reimbursement to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.
Competitive Intelligence Analysis
The publisher performs competitive and market Intelligence analysis of the LEMS market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.
Scope of the Report
The report covers the descriptive overview of LEMS, explaining its causes, signs and symptoms, risk factors, pathophysiology, pathogenesis, and currently available therapies.
Comprehensive insight has been provided into the LEMS epidemiology and treatment.
Additionally, an all-inclusive account of both the current and emerging therapies for LEMS is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
A detailed review of the LEMS market; historical and forecasted is included in the report, covering the 7MM drug outreach.
The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM LEMS market.
The increasing prevalence of the disease will positively drive the LEMS market.
The companies and academics are working to assess challenges and seek opportunities that could influence LEMS R&D.
Major players are involved in commercializing therapies for LEMS. Launch of the therapies will significantly impact the LEMS market.
In-depth analysis of the different emerging trends and comparative analysis with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.
For more information about this drug pipelines report visit https://www.researchandmarkets.com/r/zeehk7
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Global Azimuth Thrusters Market Size in 2020 Top Countries Analysis,Industry Demand, Market Share, Trend, Industry News, Business Growth, Top Key Players, Showing Impressive Growth by 2026
The past years has witnessed the decrease of global azimuth thrusters due to the shrink of global shipbuilding market. The overcapacity and reduction in offshore demand has influenced the azimuth thrusters a lot. But we can still see the demand of azimuth thrusters in major shipbuilding regions such as Europe, China, Japan and Korea.
Market Analysis and Insights: Global Azimuth Thrusters Market
The global Azimuth Thrusters market is valued at 514.5 million USD in 2020 is expected to reach 496.5 million USD by the end of 2026, growing at a CAGR of -0.5% during 2021-2026.
Global Azimuth Thrusters Market: Drivers and Restrains
The research report has incorporated the analysis of different factors that augment the market’s growth. It constitutes trends, restraints, and drivers that transform the market in either a positive or negative manner. This section also provides the scope of different segments and applications that can potentially influence the market in the future. The detailed information is based on current trends and historic milestones. This section also provides an analysis of the volume of production about the global market and also about each type from 2015 to 2026. This section mentions the volume of production by region from 2015 to 2026. Pricing analysis is included in the report according to each type from the year 2015 to 2026, manufacturer from 2015 to 2020, region from 2015 to 2020, and global price from 2015 to 2026.
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This market study covers the global and regional Azimuth Thrusters market with an in-depth analysis of the overall growth prospects in the Azimuth Thrusters market. Furthermore, it sheds light on the comprehensive competitive landscape of the global Azimuth Thrusters market. The report further offers a dashboard overview of leading companies encompassing their successful marketing strategies, market contribution, and recent developments in both historic and present contexts.
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Azimuth Thrusters market is split by Type and by Application. For the period 20152025, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.
Azimuth Thrusters provides details by vendors, including company overview, company total revenue (financials), market potential, global presence,Azimuth Thrusters sales and revenue generated, market share, price, production sites and facilities, SWOT analysis, product launch. For the period 20152020, this study provides the Azimuth Thrusters sales, revenue and market share for each player covered in this report.
The report provides an in-depth knowledge of the Global Azimuth Thrusters market scenario:
The report provides an indepth knowledge of the Global Azimuth Thrusters market scenario:
1.1 Azimuth Thrusters Introduction
1.2 Market Analysis by Type
1.3 Market Analysis by Applications
1.4 Market Dynamics
1.4.1 Market Opportunities
1.4.2 Market Risk
1.4.3 Market Driving Force
2.4.1 Business Overview
2.4.2 Azimuth Thrusters Type and Applications
220.127.116.11 Product A
18.104.22.168 Product B
3.1 Global Azimuth Thrusters Sales and Market Share by Manufacturer (20192020)
3.2 Global Azimuth Thrusters Revenue and Market Share by Manufacturer (20192020)
3.3 Azimuth Thrusters Market Concentration Rates
3.3.1 Top 3 Azimuth Thrusters Manufacturer Market Share in 2020
3.3.2 Top 6 Azimuth Thrusters Manufacturer Market Share in 2020
3.4 Azimuth Thrusters Market Competition Trend
4.1 Global Azimuth Thrusters Sales, Revenue and Market Share by Regions
4.1.1 Global Azimuth Thrusters Sales and Market Share by Regions (20142019)
4.1.2 Global Azimuth Thrusters Revenue and Market Share by Regions (20142019)
4.2 North America Azimuth Thrusters Sales and Growth Rate (20142019)
4.3 Europe Azimuth Thrusters Sales and Growth Rate (20142019)
4.4 AsiaPacific Azimuth Thrusters Sales and Growth Rate (20142019)
4.6 South America Azimuth Thrusters Sales and Growth Rate (20142019)
4.6 Middle East and Africa Azimuth Thrusters Sales and Growth Rate (20142019)
5.Azimuth Thrusters Market Forecast (20202025)
5.1 Global Azimuth Thrusters Sales, Revenue and Growth Rate (20202025)
5.2 Azimuth Thrusters Market Forecast by Regions (20202025)
5.3 Azimuth Thrusters Market Forecast by Type (20202025)
5.3.1 Global Azimuth Thrusters Sales Forecast by Type (20202025)
5.3.2 Global Azimuth Thrusters Market Share Forecast by Type (20202025)
5.4 Azimuth Thrusters Market Forecast by Application (20202025)
5.4.1 Global Azimuth Thrusters Sales Forecast by Application (20202025)
5.4.2 Global Azimuth Thrusters Market Share Forecast by Application (20202025)
6.1 Sales Channel
6.1.1 Direct Marketing
6.1.2 Indirect Marketing
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6.2 Distributors, Traders and Dealers
8.2 Data Source
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Signs of Bullish Crypto Market Expectations | Bitcoin News Summary Aug 24, 2020
Data from Google Trends indicates that there’s a massive spike in the interest in cryptocurrency. In fact, “buy crypto” searches are at their highest level since the ICO boom. At the same time, the amount of BTC held in exchange accounts was at a 2 year low. This indicates many users are withdrawing coins to more secure personal wallets. Both of these events suggest a sign of bullish market expectations.
A new paper by Blockchain Research Lab provides further evidence for wash trading. Wash trades occur when a trader buys or sells to their own account, achieving no profit or loss but increasing reported volume. This benefits both the coins and exchanges by giving a false impression of activity. The researchers called on popular data metric sites to implement stricter reporting of trading volumes.
Former head of Uber’s security team is alleged to have paid $100,000 in Bitcoin to cover up a hack of the company’s database in 2016. Joseph Sullivan has been charged with obstruction of justice and misprision of a felony for failing to disclose the hack, which is said to have exposed the data of 57 million users including drivers.
Tahini’s, a Canadian restaurant chain, is converting the entirety of its cash reserves to Bitcoin. The company’s owner tweeted explaining that the pandemic and its monetary response revealed the traditional financial system as “a game of musical chairs.”
Before we conclude, this week’s “Bitcoin quick question” is can Bitcoin be transferred into your bank account?
In most countries, Bitcoin cannot be transferred, as is, to your bank account. That is usually due to regulatory and compliance measures that banks are dealing with, as they are the government’s agent when it comes to preventing money laundering, terror financing, or other criminal activities.
However, recently there have been great advancements, and the day you will be able to hold Bitcoin in your bank looks closer than ever.
Rules that have passed in Germany will allow local banks to custody cryptocurrencies, and it is safe to assume other European countries will follow.
In the United States, the regulator of the currency, also known as the OCC, has recently clarified U.S. Banks are also allowed to hold cryptocurrencies for their customers.
Therefore, it is a matter of time before the banks will step in as well. But remember the Bitcoin rule – not your private keys, not your Bitcoin!
Have a question you want us to answer? Just leave it in the comment section below. And if you want to support our videos, consider using the Brave browser for faster, ad free browsing that can also earn you rewards. Just visit the link in the description below.
That’s what’s happened this week in Bitcoin. See you next week.
NZD losing a few points, NZ 10 yr bond yield hits a record low
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Gold Price Analysis: Continuation Pattern Appears Ahead of September
The V-shape rebound in the price of gold unravels as the Federal Open Market Committee (FOMC) Minutes foreshadow a change in the monetary policy outlook, but the pullback from the record high ($2075) may prove to be an exhaustion in the bullish price action rather than a change in trend as a continuation pattern takes shape in August.
The price of gold appears to be stuck in a wedge/triangle formation after marking the longest stretch of gains (nine consecutive weeks) since 2006, and the precious metal may continue to consolidate ahead of the Federal Reserve Economic Symposium scheduled for August 27-28 as the FOMC discusses an outcome-based approach versus a calendar-based forward guidance for monetary policy.
In turn, the Fed symposium may sway the price of gold if Chairman Jerome Powell and Co. show a greater willingness to scale back its emergency tools over the coming months, but the event may ultimately signal more of the same for the next interest rate decision on September 16 as the Fed’s balance sheet climbs back above $7 trillion in August.
In fact, it seems as though the FOMC will retain the current policy beyond the US election as the committee extends its lending facilities through the end of the year, and the macroeconomic environment may keep gold prices afloat as it trades to fresh yearly highs during every single month so far in 2020.
Looking ahead, the net-long US Dollar bias from July also looks poised to persist as the IG Client Sentiment report shows retail traders still net-long USD/CHF, USD/CAD and USD/JPY, while the crowd remains net-short AUD/USD, GBP/USD, EUR/USD and NZD/USD.
It remains to be seen if the crowding behavior will carry into September as the FOMC vows to “increase its holdings of Treasury securities and agency residential and commercial mortgage-backed securities at least at the current pace,” but the low interest rate environment along with the ballooning central bank balance sheets may continue to heighten the appeal of bullion as an alternative to fiat-currencies as the committee votes unanimously to push back “the expiration of the temporary U.S. Dollar liquidity swap lines through March 31, 2021.”
With that said, the pullback from the record high ($2075) may prove to be an exhaustion in the bullish behavior rather than a change in trend as the price of gold trades to fresh yearly highs during every single month so far in 2020, and a continuation pattern appears to be taking shape in August as the precious metal consolidates within the monthly range.
Source: Trading View
- The technical outlook for the price of gold remains constructive as it trades to fresh yearly highs during every single month so far in 2020, with the bullish behavior also taking shape in August as precious metal tags a new 2020 high ($2075).
- The price of gold cleared the previous record high recorded in September 2011 ($1921) even though the Relative Strength Index (RSI) failed to retain the upward from June, but the indicator registered a new extreme reading (88) for 2020 as the oscillator pushed into overbought territory for the third time this year.
- In turn, therecent sell-signalin the RSI could be indicative of a potential exhaustion in the bullish behavior rather than a change in trend as it recovers from its lowest reading since June, and the indicator may help to validate the wedge/triangle formation as it appears to be breaking out of the downward trend established earlier this month.
- The string of failed attempts to close below the $1907 (100% expansion) to $1920 (161.8% expansion) may keep the price of gold within a continuation pattern as it tracks the trendline from the July low ($1758), but need a break/close above the Fibonacci overlap around $1971 (100% expansion) to $1985 (261.8% expansion) to bring the $2025 (78.6% expansion) region back on the radar.
- A break/close above $2025 (78.6% expansion) opens up the record high price ($2075), with the next area of interest coming in around $2092 (161.8% expansion).
— Written by David Song, Currency Strategist
Follow me on Twitter at @DavidJSong
Author: David Song
Group demonstrates in Dixon to show support for Postal Service
DIXON — Dozens of people gathered in front of the Dixon post office Saturday morning to show support for an institution they fear is under attack from its own Postmaster General.
They came out to voice their concerns about what is happening to the US Postal Service, where Postmaster General Louis DeJoy has ordered cuts in overtime pay and the removal of high-speed mail sorting machines.
They held signs saying “US Mail not for sale” and “Support Postal Workers” and “Stamp out Fascism.”
The U.S. House of Representatives passed a bill Saturday that would give $25 billion to the Postal Service, although The Associated Press reported that it is not likely to be taken up by the Senate.
Former teacher Fran Ayars, of Dixon, called out DeJoy specifically, saying she hopes people driving past and seeing the demonstration would “maintain their support for a Constitutional directive that the United States has a post office that delivers to everybody, everywhere in this country.”
Article I, Section 8 of the Constitution empowers Congress to establish a post office.
“That was what was important in the 1700s when the Constitution was written,” Ayars said. “We’ve got to be able to communicate. It’s the most wonderful thing. It’s a community adhesive. It brings everyone together.”
Most who drove past seemed supportive of the message, with several honking and waving.
Kraig Schweiss came from Sterling to call out the White House for closing down services he says are extremely important to many Americans. He worries about what might happen if the Postal Service is the victim of major cutbacks.
“All of the veterans and elderly and people coming down with COVID, a lot of their medication is going to be coming through the mail,” Schweiss said. “That’s going to be stifled. We’ll have even more people that die because of Trump’s selfishness and his toxic narcissism.”
Sarah Bingaman, a native of Dixon, is a member of Action for a Better Tomorrow Sauk Valley, the group that organized the rally.
“It’s a great day to support our USPS,” Bingaman said. “We have seen signs all around town supporting our health care workers, and we are so thrilled to see that. We think our health care workers should all be supported.
“We’ve heard a lot of support for our teachers, all our school personnel, our school board members, but we haven’t seen a lot of support for our USPS, our letter carriers who have worked throughout this pandemic, never missed a day, never hesitated to do their jobs. We thought it was time to say thank you to all of our postal workers.”
Bingaman sent a message with her sign, reading “USPS, thank you for making vote by mail secure” but also sent a message with her face mask. It read “vote.”
Author: By Eric InglesEmailFollow